Analysis of HPV genotypes and liquid-based cervical cytology: Results from a tertiary academic center in northwestern Turkey.

High-risk human papilloma virus (hrHPV) plays an important role in the cause of cervical cancer. The aim of this study is to investigate the distribution of HPV genotypes in the region and to correlate with the liquid-based-cytology (LBC) and colposcopic biopsy results. Furthermore, the potential relationship between HPV infections and bacterial vaginosis (BV) was investigated. HPV genotypes were determined by real-time PCR using a commercial kit at molecular microbiology. LBC, biopsies and BV examinations were performed at Pathology& Cytology. The consecutive cervical specimens of 409 women having both of cytology and HPV-DNA tests were included in the study. A total of 172(42.1%) patients [107(26.2%) with hrHPV] had HPV-DNA positive. The most common HPV genotypes were HPV 59,16,33,52, 51 (16.6%,15.9%,13.4%,13.4%,8.9%) respectively. Epithelial cell abnormality was detected in 11.5% of the LBC tests. The genotypes of HPV 33,56, 66, and 68 were found at a higher rate in patients who had epithelial cell abnormalities than in those with no detected abnormalities. Bacterial vaginosis was found in 24 (5.9%) of the patients. HPVDNA positivity was observed statistically higher in patients with BV than non-BV.