Hemisynthesis of rhazinilam analogues: structure - activity relationships on tubulin-microtubule system
1997
Abstract Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed.
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