The Chemistry of the Quinolones: Chemistry in the Periphery of the Quinolones

Numerous reviews have been published to date on the structure-activity relationships of quinolones (Andriole 1988; Asahina et al. 1992; Domagala 1994; Mitscher et al. 1990, 1993; Radl 1990; Rosen 1990; Schentag and Domagala 1985; Wentland 1990); therefore these will be mentioned only briefly in connection with the discussion of chemical reactions. This chapter focuses on the chemistry of the quinolone parent substance. There have also been several reviews published on the chemistry of quinolones (Albrecht 1977; Bouzard 1990; Chu 1993; Chu and Fernandes 1991; Lesher 1978; Leysen et al. 1991a,b; Radl and Bouzard 1992; Mitcher et al. 1988).