Synthesis of (Arylamido)pyrrolidinone Libraries Through Ritter-Type Cascade Reactions of Dihydroxylactams.

Peng Wu,Michael Åxman Petersen,Rico Petersen,Martin Ohsten Rasmussen,Karine Bonnet,Thomas E. Nielsen,Mads Hartvig Clausen

Synthesis of (Arylamido)pyrrolidinone Libraries Through Ritter-Type Cascade Reactions of Dihydroxylactams.

2016

Peng Wu
Michael Åxman Petersen
Rico Petersen
Martin Ohsten Rasmussen
Karine Bonnet
Thomas E. Nielsen
Mads Hartvig Clausen

The Ritter-type reaction of arylnitriles and N-acyliminium ions, generated in situ from dihydroxy-γ-lactams gives tetrahydropyrrolooxazolones in excellent yields.

Keywords:

Cascade
Ion
In situ
Organic chemistry
Chemistry
pyrrole derivatives

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