Does nutritional status affect treatment tolerability and efficacy in metastatic colorectal cancer (mCRC) patients? Results of a prospective multicenter study.

e14018 Background: Malnutrition (MN) could reduce survival, tolerance and response to treatment, as well as quality of life of patients (pts) in numerous cancers. Data involving mCRC are scarce and often outdated. The purpose of this study was to evaluate, in mCRC pts, the effect of MN on survival and tolerance to modern chemotherapeutic regimens, and to identify a suitable measurement method to assess their nutritional status. Methods: In this prospective, multicentric study, demographic, oncologic and nutritional data, including various nutritional indexes already used in cancerology (Nutritional Risk Index [NRI], Prognostic Inflammatory and Nutritional Index [PINI], nutritional evaluation according to the French National Accreditation and Evaluation in Health Agency [ANAES] and weight loss during the past six months [Δ weight]) were prospectively collected in all mCRC consecutive pts for 15 days in 8 hospitals in France. Chemotherapy related toxicities were graded according to the NCI-CTC, V3.0. Surviv...