Enantiomers of 2-hydroxy derivatives of fatty acids and their use as medicaments.
2011
Enantiomers of 2-hydroxy derivatives of fatty acids and their use as medicaments. The present invention relates to a method of separating the enantiomers (or optical isomers) [-] and [+] of compounds 2-hydroxy derivatives of fatty acids, the enantiomers themselves, pharmaceutical compositions comprising them and their use as medicines. The present invention also covers a method of in vitro diagnosis / prognosis of said diseases based on the expression level of said enzyme EC 2.7.8.27, and a kit comprising means specially designed to carry out the diagnosis / prognosis. In addition, EC 2.7.8.27 enzyme can be used as a therapeutic target for screening candidate compounds for the treatment and / or prevention of diseases mediated by it.
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