Effectiveness of cerclage according to severity of cervical length shortening: A meta-analysis

Objectives To estimate the effectiveness of cerclage according to degree of cervical length (CL) shortening. Methods A meta-analysis was carried out of trials of women with singleton gestations and second-trimester transvaginal sonographic CL < 25 mm randomized to cerclage or no cerclage. The degree of CL shortening was correlated to the efficacy of cerclage in preventing preterm birth. Results There was a significant reduction in preterm birth < 35 weeks in the cerclage compared with no cerclage groups in 208 singleton gestations with both a previous preterm birth and CL < 25 mm (relative risk, 0.61; 95% CI, 0.40–0.92). In these women, preterm birth < 37 weeks was significantly reduced with cerclage for CL ≤ 5.9 mm, ≤ 15.9 mm, 16–24.9 mm and < 25 mm. None of the analyses for 344 women without a previous preterm birth was significant. Conclusions Cerclage, when performed in women with a singleton gestation, previous preterm birth and cervical length < 25 mm, seems to have a similar effect regardless of the degree of cervical shortening, including CL 16–24 mm, as well as CL ≤ 5.9 mm. Copyright  2010 ISUOG. Published by John Wiley & Sons, Ltd.