Highly Efficient and Stable Strain-Release Radioiodination for Thiol Chemoselective Bioconjugation
2018
We report a novel thiol selective radioiodination method based on strain-release reaction. A new heterobifunctional radioiodination agent which has very good thiol selectivity and excellent stability with high radiolabeling yield was synthesized, characterized, and applied successfully for thiol-contained peptide labeling.
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