Enantioselective Cooperative Triple Catalysis: Unique Roles of Au(I)/Amine/Chiral Broensted Acid Catalysts in the Addition/Cycloisomerization/Transfer Hydrogenation Cascade.

An enantioselective, cooperative process involving the concerted action of three different catalysts is realized for the synthesis of 2-substituted tetrahydroquinolines (III) from 2-aminobenzaldehydes (I) and alkynes (II).