Towards Parkinson’s Disease Prognosis Using Self-Supervised Learning and Anomaly Detection

Parkinson’s disease (PD) is a chronic disease with a high risk of incidence after the age of 60 and is a problem for many countries facing an aging population. Current works have mainly focused on supervised learning using data collected from various sensors to differentiate between PD and healthy subjects. However, such supervised methods are not ideal for prognosis where there are no labels (i.e., we do not know in advance which subjects will develop PD in the future). We propose to tackle the problem as a semi-supervised anomaly detection task, where we model the physiological patterns of healthy subjects instead. A self-supervised learning technique first learns a good representation of the sensor signals. The representations are then adapted to capture inter-class patterns for anomaly detection. Evaluation on a large-scale PD dataset shows that our approach can learn discriminative features.