Expressions of SATB1, survivin and VEGF in ovarian epithelial cancer and their clinical significance

Objective: To investigate the expressions of special AT rich sequence- binding protein-1 (SATB1), survivin and vascular endothelial growth factor (VEGF) in epithelial ovarian cancer tissues and to analyze their clinical significance. Methods: The expressions of SATB1, survivin and VEGF in normal ovarian, ovarian serous cystadenoma and ovarian epithelial cancer tissues were detected by immunohistochemistry. The relationships of the expressions of SATB1, survivin and VEGF with the clinical and pathological characteristics and the prognosis of patients with ovarian epithelial cancer were analyzed. Results: The positive expression rates of SATB1, survivin and VEGF in ovarian epithelial cancer tissues were higher than those in ovarian serous cystadenoma and normal ovarian tissues (all P < 0.05). The expression of SATB1 was correlated with lymph node metastasis and ascites (both P < 0.05). The median survival time of patients with positive expressions of SATB1, survivin and VEGF was shorter than that of the patients with negative expressions (all P < 0.05). SATB1, survivin, VEGF and International Federation of Gynecology and Obstetrics (FIGO) stage were independent prognostic factors of patients with epithelial ovarian cancer (all P < 0.01). Conclusion: The positive expression rates of SATB1, survivin and VEGF in ovarian epithelial cancer  tissues are higher. The expression of SATB1 is related to lymph node metastasis and ascites. The prognosis of SATB1, survivin and VEGF positive expression of patients with ovarian epithelial cancer is poor. DOI:10.3781/j.issn.1000-7431.2016.33.152