Menapoz Sonrası Dönemde Farklı Hormon Replasman Tedavilerinin Göz Yaşı Fonksiyonlarına Etkileri

Objectives: The effects of various hormonal replacement treatments (HRT) on tear functions in postmenopausal women were evaluated. Material and Methods: The study group consisted of 84 postmenopausal women, 26 patients using conjugated estrogen (Group1), 15 patients using conjugated estrogen + medroxyprogesterone acetate (Group 2), 19 patients using Tibolone (Group 3) and 24 patients as control group (Group 4). Schirmer test was performed and tear break up time (BUT) was measured. The mean of right and left eye measurements were used in the study. Groups that receiving HRT were compared with each other and with control group. Results: Mean age of 84 postmenopausal women was 51.97±5.70 years. Mean value of right and left eye Schirmer test was 18.57±3.98 mm in group 1, 20.80±2.84 mm in group 2, 21.00±5.05 mm in group 3, and 13.75±3.49 mm in group 4. Mean tear BUT was 12.05±3.45 sec. in group 1, 12.90±2.13 sec. in group 2, 14.00±2.77 sec. in Group 3, 8.10±3.21 sec. in Group 4. Schirmer test results and tear break up time of all groups that receive HRT were statistically higher than the control group. There was no statistical significant difference between the HRT receiving groups. Conclusion: HRT, independent from its content, preserves tear functions in postmenopausal women..©2008, Firat University, Medical Faculty.