Study of Role Of Plasmapheresis in Patients With Guillain Barre Syndrome

BACKGROUND : Guillain-Barre Syndrome (GBS) is an acute, frequently severe and fulminant polyradiculoneuropathy that is autoimmune in nature. We conducted study of 50patients of GBS admitted during period of Sep-2013 to Nov-2015. METHODS : we have enrolled patients who had been diagnosed as Guillain–Barre Syndrome ,fulfil the diagnostic criteria from the National Institute of Neurological Disorders and Stroke (NINDS) 1990 (Asbury and Cornblath, 1990). all 50 patients received plasmapheresis. Plasmapheresis was done in IHBT department, CHA with Baxter plasmapheresis machine (continuous flow). Plasmapheresis cycles were done as per severity of disease and clinical condition of the patient. Most patients received 4-5 cycle of 50ml/Kg exchange was done over 8-13 days through femoral or central venous catheter. For allpatients, clinical assessment was done initially at a time of admission, then at 2 weeks, 4 weeks and 8 weeks after treatment with plasmapheresis. RESULTS : Percentage of patients recover walking with aid and without aided at the end of 4 weeks after treatment with plasmapheresis were 50% and 24% respectively . At the end of 4