Drug Delivery with Organic Solvents or Colloidal Dispersed Systems

The choices for drug delivery options based on organic solvents and colloidal dispersed systems are discussed by route of administration. Key physicochemical properties and dosage forms of marketed oral and parenteral drugs are exemplified. For oral dosing, dissolution enhancement with nanoparticles and supersaturating delivery systems like solid dispersions or lipid based delivery systems are presented. For parenteral drug delivery route, dosage form and excipient considerations are presented. For enabling injectability of highly dosed poorly water soluble drugs, solubilization by cosolvents, micelles, emulsions and liposomes are explained. Drug targeting by liposomes, nanoparticles, stabilized micelles, antibody drug conjugates, ligand targeted nanocarriers and also intracellular siRNA delivery are described. Injection depot dosage forms are featured that rely on controlled drug release and enable convenient dosing for chronic treatment.