Identification of high-risk Brugada syndrome patients by combined analysis of late potential and T-wave amplitude variability on ambulatory electrocardiograms.

Background: Risk stratification is important in the management of Brugada syndrome (BrS). Late potentials (LPs) and T-wave amplitude variability (TAV) in high-resolution ambulatory electrocardiography (ECG) were retrospectively investigated. Methods and Results: One hundred and twenty-seven patients diagnosed with BrS on 12-lead ECG were classified into 3 groups: documented ventricular fibrillation (VF)/asystole (n=19), episodes of syncope alone (n=30), and asymptomatic (n=78). Healthy volunteers were enrolled as controls (n=25). In the BrS patients, LPs showed appreciable circadian periodicity; filtered QRS duration (fQRS) and duration of the terminal low-amplitude signal syncope/asymptomatic>control (P 116ms, LAS40 >35ms, RMS40 54μV); VF/asystole was discriminated from syncope/asymptomatic at a ratio of 60–69%, by night-time LPs (fQRS >122ms, LAS40 >42ms, RMS40 58μV). Combined analysis of LPs and peak TAV increased the discriminant ratio up to 93% and 77%, respectively. Conclusions: Analysis of both LPs and TAV (taking circadian periodicity into account) is useful in identification of high-risk BrS patients.  (Circ J 2013; 77: 610–618)