Nicardipine inhibits the endothelin-1-induced constriction of systemic capacitance and resistance vessels

We estimated the effects of intravenous injection of endothelin-1 (ET-1; 400 pmol/kg) on the systemic capacitance and resistance vessels in anesthetized mongrel dogs by measuring changes in the mean circulatory pressure (MCP) and total peripheral resistance (TPR),respectively. In addition, the present study investigated the inhibiting action of nicardipine (NIC; 10 μg/kg bolus injection followed by 1.0-2.0 μg/kg/min continuous infusion) against the vasoconstrictor action of ET-1