Clinical studyAngina pectoris among 10,000 men: 5 Year incidence and univariate analysis☆

In 1963, 10,000 men aged 40 years and over were examined; those without myocardial infarction or angina pectoris were followed for the next 5 years (1963–1968) to see what factors (variables) found in 1963 were associated with the development of angina pectoris by 1968. The average annual adjusted incidence for angina pectoris was 7.2/1,000; the incidence was highest (11.2) in those bom in Southeastern Europe and lowest (3.8) in those born in the Middle East. The incidence rose with age until age 59 and then plateaued off. The variables found significantly associated (p <0.01) with the development of angina pectoris were as follows: Clinical—blood pressure (systolic and diastolic), intermittent claudication, diabetes mellitus, nonspecific T waves in the electrocardiogram, serum cholesterol (total and in beta-lipoprotein). Psychosocial—anxiety and severe problems as seen by the subject in whatever area of his life situation, as well as, or because of, moving from one country to another. Blood group—A1BJka−. In addition, overweight, peptic ulcer and lack of physical activity are probably of importance. A knowledge of the factors associated with the development of angina pectoris is a “sine qua non” for the clinician who is interested in preventing the condition or aiding the patient who already has it.