Bioactive Natural Leads Targeting Cancer Cell Metabolism

Therapeutic interest in targeting cancer metabolism has become emerging in recent years. However, a very few numbers of molecules has been identified as a potential modulator of cancer cell metabolism and are in the investigation. Therefore discovery and development of potent and selective drugs from natural sources like plants, marine organisms, or invertebrates are very essential to check the global health disaster because of cancer. To address these emerging complications potential leads from the natural origin are a judicious choice of interest. An organized and summarized evidence concerning cancer cell metabolic proteins and natural lead molecules against cancer cell metabolism with an emphasis on molecular/cellular mechanism(s) is crucial in a single podium. This chapter precisely discusses the antimetabolic potential of natural lead molecules and their mechanisms of action (MOA) against cancer cell metabolism. This complete review on different molecular mechanisms of bioactive leads will toward cancer cell metabolism support researchers in understanding the targetable metabolic protein and their interacting pathways, to discover safe and potent drugs for better therapeutic applications against cancer.