Chrysin: A Promising Anticancer Agent its Current Trends and Future Perspectives
2018
Cancer is one of the major public health concerns in the
United States and in other developed countries, affecting
million deaths approximately every year worldwide. Cancer
incidences show inconsistency between emerging and
developed nations. Epidemiologic findings intensely
propose that incidence of cancer are predisposed by environmental factors including diet, which is essentially
unavoidable. Strategies to prevent cancer comprise
overlapping approaches viz. Dietary cancer prevention or
chemoprevention. Naturally occurring constituents or
pharmacological agents prevent or reverse the initiation
phase of carcinogenesis or arrest at progression of
carcinogenesis through chemoprevention. Cancer
prevention through diet may be possible by the intake of
fruits and vegetables. Significant consideration has been
given in finding plant-derived dietary agents, which can be
developed as promising chemo preventives. One such
compound is chrysin (5,7-dihydroxylflavone). It has been
shown to possess significant anti-inflammatory, antioxidant
and anti-carcinogenic properties. Recently significant
progress has been made in studying the biological effects of
chrysin at cellular and molecular levels. This review
scrutinizes the anticancer effects of chrysin, its considerable
potential for development as a cancer chemo preventive
agent.
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