Drug-Induced Disorders of Glucose Tolerance

Purpose: To review the medications that influence glucose metabolism and to examine the mechanisms of these medications on glucose metabolism. Data Sources: Data were obtained from a MEDLINE search back to 1966 and included animal and human studies published in the English language. Study Selection: Approximately 80% of original publications were included after review by the authors. Case reports were included if they provided additional information. Date Extraction: The original data from the literature were included on the basis of independent extraction by the authors. Data Synthesis: Many common therapeutic agents influence glucose metabolism. Multiple mechanisms of action on glucose metabolism exist through pancreatic, hepatic, and peripheral effects