Metagenomics and methods development for the determination of antibiotics and AMR/ARGS

Abstract In recent times, the introduction of a varied range of antibiotics has helped to effectively reduce the effects of bacterial infections. However, the evolution and procurement of antibiotic-resistance in certain bacteria has led to increased cases of mortality. This is a result of abuse and overprescription of antibiotics. Despite the difficulties associated with antibiotic resistance in infectious bacteria, only a limited amount of information is known regarding the distribution, diversity, and origin of resistance genes. The area of antibiotic drug discovery and public health monitoring of antimicrobial resistance have started to utilize the capabilities of genomic and metagenomics sequencing. The application of high-throughput genomic tools provides new avenues for environmental health monitoring. This includes metagenomics-based investigation of antibiotic resistance determinants Metagenomics has helped to improve the understanding of the mechanisms of antibiotic resistance in natural and clinical environments. This review discusses recent findings and future obstacles in the area of antibiotic resistance analysis through metagenomics.