AB0271 FACTORS ASSOCIATED WITH HOSPITAL ADMISSIONS MORTALITY IN RHEUMATOID ARTHRITIS PATIENTS IN SPAIN. (TREND-AR STUDY)

Background There have been significant changes in the management of rheumatoid arthritis (RA) during the past 20 years. The potential impact of these changes on hospital admissions mortality is unknown. Objectives To analyse the factors associated with hospital admissions mortality in rheumatoid arthritis patients in Spain from 1999 to 2015. Methods This is a retrospective population study. We have analized a national administrative database that includes a Minimum Basic Data Set (MBDS) of hospital admissions of RA patients during the period 1999 to 2015. We studied all the cases of hospital admissions mortality. Patients were identified by concatenation of clinical record number and birth date. The analyzed factors were identified by the presence in primary and secondary diagnosis of the ICD9 codes, during the first hospital admission. Hazard Ratio (adjusted by sex and age) were calculated using Cox regression analyses. Results There were a total of 338.343 hospital admissions in RA patients during the study period, accounting for a total of 186.491 patients (127.203 women (68,21%) and 59.288 men (31,79%). The mean number of hospital admissions was 1,81(SD 1,7), with a minimum of 1 and a maximum of 43. The median time of follow-up was 11,85 months (DE 27,4). There were a total of 18.641 exitus (5,5%). The HR (adjusted by sex and age) of the factors associated with hospital admissions mortality are shown in the next table: Conclusion In Spain, during the period of 1999-2015, the factors associated with hospital admission mortality (first admission) are: age, male sex, higher Charlson Index and longer hospital stay. The associated clinical variables are chronic hepatopathy, amyloidosis and neoplasm. Disclosure of Interests: None declared