[Role of microRNA in primary open-angle glaucoma].

The pathogenesis of primary open-angle glaucoma (POAG) is still unclear. The trabecular meshwork (TM) plays an important role for regulation of aqueous humor outflow. The alteration of morphology, structure of TM cells and expression of extracellular matrix (ECM) components contribute to the abnormal increase of outflow resistance leading to elevated intraocular pressure (IOP). Recently, it has been confirmed that a variety of microRNA (miRNA) such as miRNA-29, 24, 200c and so on were expressed in TM tissue and different miRNA can affect the TM function and the synthesis of ECM in different ways. In this paper, we will review the role of miRNA in POAG pathogenesis, in order to provide the basis for probing into pathogenesis of glaucoma. (Chin J Ophthalmol, 2016, 52: 476-480) Key words: Glaucoma, open-angle; MicroRNAs; Trabecular meshwork; Extracellular matrix; Transforming growth factor beta2