Long-term outcome and prognostic factors in 80 women treated for ovarian yolk sac tumor

5547 Background: Ovarian yolk sac tumor (YST) is a very rare malignancy arising in young women. Due to the rarity of this tumor, only few retrospective series have been published. Our study was aimed to evaluate the long-term outcome and to identify prognostics parameters, which might help to make appropriate risk-based decision about therapy. Methods: This retrospective study is based on prospectively recorded ovarian YST cases at the Institut Gustave-Roussy. Pediatric cases were excluded. Survival curves were estimated by the Kaplan-Meier method. Univariate analysis using the log-rank test tested possible associations between survival and patient (pt) or disease covariates. Multivariate analysis was performed using a model of logistic regression including age, stage (FIGO), presence of ascites at diagnosis, and chemotherapy regimen. Results: Between 1976 and 2006, 80 pts were registered. Median post operative AFP was 1,700 (2 - 154,000) ng/mL. Since 1991, most of the pts have undergone fertility-sparing...