Evaluation of Metastatic Cholangiocarcinoma in a Spitz Dog

A 12-year-old spitz breed dog, with progressive neurologic symptoms including seizures, ataxia, mental depression, walking aimlessly and head pressing was referred to Small Animal Hospital of Veterinary Medicine, the University of Tehran. The dog was received Diazepam prior to examination and diagnosis, whereas it died at first day eventually. In physical examination, there was a firm mass with irregular nodular surface, about 8 cm in diameter under the skin of mammary glands region. At necropsy, considerable abdominal ascites, several masses with different sizes throughout liver lobes and on intestinal serosa were observed. According to histological adjectives of biliary epithelium due to firm texture of the tumour masses and numerous mitotic figures the tumour was confirmed as cholangiocarcinoma, and immuniohistochemical results for cytokeratin marker demonstrated such diagnosis.