Análisis de variables relacionadas con el índice de deterioro cognitivo del wais en un grupo de pacientes con epilepsia

Se estudio un grupo de 125 pacientes epilepticos con el proposito de conocer la existencia de indice de deterioro cognitivo positivo y la relacion del deterioro con un conjunto de variables multicausales (biologicas, sociales y medicamentosas). Se aplico el indice de deterioro de Weshcler del cuestionario de epilepsia a los pacientes en estudio, los cuales fueron divididos en 2 grupos: los que tenian deterioro cognitivo y los que no lo tenian. Los datos se procesaron con estadigrafos como Fisher, Chi-cuadrado, Odds Ratio, y analisis estadistico multivariado (ANOVA). El deterioro se presento en el 29 por ciento de los pacientes estudiados; en mas del 80 por ciento de los pacientes con epilepsia y alcoholismo (Fisher p = 0,012 diferencia significativa y Odds Ratio = 6,532); en el 68 por ciento de los que tenian elevada frecuencia de crisis (p = 0,0014 Odds Ratio = 8,075); en el 83 por ciento de los que tenian psicosis asociada (p = 0,0126 Odds Ratio = 6,531); en mas del 60 por ciento de los que tomaban fenitoina (Anova p = 0,0082) y en los que la tomaban de forma combinada con carbamazepina (p = 0,0210 Odds Ratio = 27,00). La tercera parte de los pacientes con epilepsia presentan deterioro cognitivo. La epilepsia asociada al alcoholismo y la elevada frecuencia de crisis son los factores biologicos mas deteriorantes. La psicosis asociada a epilepsia tiene alta incidencia de deterioro. La fenitoina es el FAE que produce mas deterioro y su uso unido a la carbamazepina no es recomendado. Based on a research study done on a group of patients suffering from epilepsy the existance of positive cognitive deterioration and its relationship with a multicausal group of variables were found out. For this study we used Wechsier's Deterioration Indicator applied on 125 patients suffering from epilepsy.These patients were classified into two groups: the ones suffering from positive deterioration and the ones that were not. The relationship between deterioration and multicausual factors ( biological, social and those due to medication) was established. Data were processed with the use of stadigraphs such as Fisher, Chi - cuadrado, Odds Ratio and Multivaried Statistical Analysis (ANOVA) . Deterioration was present in 29 percent of the studied patients. In more than 80 percent of the patients suffering from epilepsy and alcoholism ( Fisher p=0.012 significant difference and Odds Ratio =6.532), in 68 percent of the patients suffering from high frequency crisis ( p=0.0014 Odds Ratio =8.075). In 83 percent of the patients suffering from associated psychosis (p=0.0126, Odds Ratio =6.531), in more than 60 percent of the patients that were administered Fenitoine (ANOVA p= 0.0082) and in the ones that were administered Carbamazepine combined with Fenitoine (p= 0.0210 Odds Ratio = 27.00). A third of the patients suffering from epilepsy present deterioration. Epilepsy associated to alcoholism and a high frequency crisis are the biological factors more deteriorating; also psychosis associated to epilepsy presents a high rate of it. The antiepeliptic pharmac (FAE) that produces more deterioration and it is not recommended to administer together with carbamazepine is Fenitoine.