Molecular-biological problems of drug design and mechanism of drug action

The cytotoxicities of capecitabine (Lab Tutour, Argentina) and xeloda (Roche) have been compared with respect to MCF-7 (human breast cancer cell line), HT-12 (colon cancer), and rat thymocytes by the MTT test. The cytotoxic activities of both drugs were the same and were highly selective with respect to the tumor cells. The sensitivity of the cells to the cytostatics increased in the order thymocytes < HT-12 < MCF-7.