Correlative analysis between plasma concentration and clinical efficacy of aripiprazole

AIM:To study the relationship between plasma concentration and clinical efficacy of aripiprazole for Chinese schizophrenics.METHODS:Aripiprazole plasma sample concertations were determined by HPLC-MS,efficacy was measured by the Positive and Negative Syndrome Scale(PANSS)scores,and the relationship between plasma concentration and clinical efficacy of aripiprazole was conducted by SPSS 11.0. RESULTS:The peak concentrations of aripiprazole on the weekends 1,2,3,4 were not correlative with the decreased ratios of PANSS scores,which were positive correlation with the average steady state trough tions of aripiprazole in weekends 3 and 4(r＞0.500,P＜0.05).The PANSS scores at the concentration above 350.0μg·L~(-1) decreased significantly eomparing with the lower concentration(P＜0.05).CONCLUSION:The steady state trough concentrations of aripiprazole are correlative with the efficacy seores,with better results above 350.0μg·L~(-1).