Avaliação clínico-laboratorial na doença de Kawasaki e marcadores da formação de aneurisma coronariano Clinical and laboratorial trends in kawasaki disease and development of coronary artery

Abstract Clinical and laboratorial trends in Kawasaki diseaseand development of coronary artery aneurisms.Kawasaki Disease is characterized by its potentialcardiovascular damage, mainly coronary arteriesaneurysms. The aim of this study was to describethe clinical criteria characteristics, other clinicalmanifestations, laboratorial changes andcardiovascular lesions of the Kawasaki Disease in36 patients followed in Children’s Institute ofClinical’s Hospital of Medical School of Sao Paulo’sUniversity. It was clinically observed: fever in 36patients (100%), rash in 35 patients (97.2%),mucous changes in 36 cases (100%), changes inperipheral extremities in 35 patients (97.2%),conjunctivitis in 31 cases (86.1%) and limph nodeswelling in 23 patients (63.9%). Laboratorialfindings included leukocytosis (15,327/mm 3 ),trombocytosis (511,700 / mm 3 ), pyuria (57,616 / mL),elevation of erythrocyte sedimentation rate (41.2mm/hour), elevation of mucoproteins (7.5 g%).Cardiac involvement consisted in coronaryabnormality in eight patients (22.2%), giantcoronary aneurysm in three cases (8.3%), valvularinsufficiency in five patients (13.9%), and pericardialeffusion in four cases (11.1%). Fever duration wasthe only single factor associated to coronary arteryabnormalities (p< 0.05). It was not possible toidentify others clinical or laboratorial markersrelated to cardiovascular complications.