Crystal forms of vortioxetine organic acid salt and preparation method thereof

The invention belongs to the technical field of medicines and particularly relates to vortioxetine p-hydroxy benzoate comprising an anhydrous crystal form and a hydrate crystal form of vortioxetine p-hydroxy benzoate as well as a preparation method and application of vortioxetine p-hydroxy benzoate. The preparation method comprises the following steps of reacting vortioxetine and p-hydroxy benzoic acid in an organic solvent or a mixed solvent system of an organic solvent and water to produce salt, carrying out heat preservation or cooling and crystallizing to obtain vortioxetine p-hydroxy benzoate. The solubility, stability, flowability, compressibility and the like of prepared vortioxetine p-hydroxy benzoate are greatly improved compared with those of vortioxetine, which is conductive to preparing pharmaceutical preparations and improving the quality.