Diode laser monitor for singlet molecular oxygen

Monitoring singlet molecular oxygen ( 1 O 2 ) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet oxygen monitor based on a pulsed diode laser technology. In this paper, we present results of singlet oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet oxygen monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.