SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL SUBSTITUTED CIS-STILBENE DERIVATIVES

In the present study novel derivatives of substituted cis-stilbene were prepared from benzyl (chloro) triphenyl phosphorane, substituted phenyl acetic acid and evaluated for their in vitro antimicrobial activity against two Gram positive strains (Staphylococcus aureus, Bacillus subtilis), two Gram negative strains (Protease vulgaris, Escherichia coli) and fungal strain Candida albicans and Aspergillus niger. The newly synthesized compounds were characterized by IR, 1 H NMR and Mass analyses. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Among the synthesized 30 derivatives 1e, 1i, 1n, 1o, 2d, 2f, 2h, 3b, 3d were found to be most effective antimicrobial compounds.