Multiple scattering anisotropy contrast using localization-diverse OCT

Multiple scattering and angle-dependent scattering anisotropy confound interrogation of tissues with OCT and are generally considered noise. Here we characterize a new localization-diverse OCT system that measures the scattering through a pair of neighboring locations. By varying the offset and direction between the locations, we could distinguish single- from multiple-scattering in tissue-mimicking scattering phantoms. This system has the potential to detect previously unobserved tissue anisotropy by leveraging localization diversity in OCT.