The Influence of DCs Loaded with Tumor Antigens on the Cytotoxic Response of MNC Culture Patients with Oncology

Currently, one of the most promising approaches for the treatment of oncological patients is the selective activation of T-cell antitumor immunity using immune cells. The generation of functionally active DCs in vitro constitutes a promising approach in the development of DC-based anticancer vaccines to mobilize patient defense systems, because their activation by tumor-specific antigens to induce cytotoxic responses, and their increased efficiency of antigen presentation to induce cytotoxic T lymphocytes (CTLs) via costimulatory molecules and cytokines can be controlled. The purpose of this study was to investigate the functional characteristics of peripheral blood DC subsets in colorectal cancer (CRR), breast cancer (BC), and non-small cell lung cancer (NSCLC) patients and the development of an antitumor cytotoxic response by mononuclear cells (MNCs) from patients using in vitro generated antigen-primed DCs.