Effect of Four Dopamine Receptor Antagonists on Gastrin Secretion in Healthy Subjects

The effect of 1 week of oral treatment with four antidopaminergic drugs—metoclopramide, sulpiride, haloperidol, and pimozide—on fasting and meal-stimulated serum gastrin levels has been evaluated in healthy subjects. All of the four drugs significantly reduced the gastrin response to a meal, whereas basal concentration was unaffected. It is suggested that this action is mediated by central nervous system dopamine receptor blockade, which might act either via nervous or humoral mechanisms to inhibit gastrin release.