Synthesis of hybrids compounds by Click Chemistry and their bioactivities
2013
In this work, a collection of hybrid compounds of type 1 (Scheme 1) were synthesized by a convergent route as potential anthelmintic drugs. One fragment of the hybrids is an oxazole or thiazole prepared from a serine dipeptide. 1 The other domain, are a dihydropyran obtained by Prins’s cyclization, functionally with ethynyl moiety by Corey-Fusch reaction. 2 Both heterocycles were coupled using the Huisgen s reaction by a triazol. 3
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