OP0310 Prevalence of risk factors and cardiovascular events across psoriatic arthritis patients treated with biological therapy

Background Psoriasis and psoriatic arthritis (PsA) are described as associated with more frequency of risk factors and cardiovascular events. Objectives To determine the prevalence of risk factors and cardiovascular events in a cohort of patients with PsA treated with biological therapy and its correlation with gender. Methods We included all PsA patients (met CASPAR criteria) following treatment with bDMARDs (reference population 2.055.000). We obtained data of high blood pressure, hyperlipidemia, hyperuricemia, type 2 diabetes mellitus, obesity (BMI ≥30), non-infectious liver disease, ischaemic cardiopathy, myocardial infarction, ischaemic stroke or transient ischaemic attack. For this analysis included gender, age, disease duration, current bDMARDs with or without current co-medication with csDMARDs and HLA-B27 status. Continuous variables were reported as mean ±standard deviation. Categorical variables were reported as percentages and frequencies. All analyses were performed using SPSS software. Differences were considered statistically significant if p Results Data were obtained from 598 PsA patients who have been treated with bDMARDs. Three-hundred and twenty-five (54.3%) patients were men, mean age was 53.3±12.6 years (men 53.3±12.9 and women 53.2±12.3, p=0.943) and disease duration of PsA was 12.4±8.7 years. No differences were seen for disease duration of PsA, nail disease, dactylitis, uveitis or HLA-B27. The prevalence of high blood pressure, hyperlipidemia, hyperuricemia, type 2 diabetes mellitus, obesity, non-infectious liver disease, ischaemic cardiopathy, myocardial infarction (MI) and ischaemic stroke/transient ischaemic attack (IS) was 36.0%, 43.6%, 16.0%, 12.5%, 26.3%, 12.5%, 5.5%, 3.8% and 1.3%, respectively. Men had most prevalence of type 2 diabetes mellitus, hyperuricemia, non-infectious liver disease, ischaemic cardiopathy, myocardial infarction and brain stroke event (see table 1). Patients with MI or IS had more prevalence of CV risk factors. Conclusions Type 2 diabetes mellitus, hyperuricemia, non-infectious liver disease, ischaemic cardiopathy, myocardial infarction and brain stroke event were more prevalent in men than in women with PsA. Male gender had correlation with the prevalence of cardiovascular events or their risk factors. Reference [1] Husted JA, et al. Cardiovascular and other comorbidities in patients with psoriatic arthritis: A comparison with patients with psoriasis. Arthritis Care Res (Hoboken)2011Dec;63(12):1729–35. Acknowledgements The authors are grateful for the support of the members of the Galician Society of Rheumatology (SOGARE) Disclosure of Interest None declared