Use azetidine compounds, and compositions thereof as inhibitors of soluble epoxide hydrolase

Provided that the compound of Formula I, stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein A, L1, L2, R1 and R2 are as defined herein, such a compound used as a soluble epoxide pharmaceutical compositions and methods of hydrolase inhibitors. R1-L1-A-L2-R2.