Abstract 5524: Prostate cancer risk assessment model (PCRAM): a scoring model based on the Swedish Family-Cancer Database

Background: Many prostate cancer (PC) risk assessment models have been developed, however almost none include familial history. We aimed to produce a risk assessment model for PC based on familial background of related cancers. Method: 976,859 independent index men aged >=30 in year 1998 and their family members in the Swedish Family-Cancer Database (FCD 2010) were randomly divided into the development (60%) and the validation (40%) datasets (follow-up=10 years). The hazard ratio from Cox model for personal and family history was used to extrapolate risk scores. Results: Specified scores were for PC in situ at age =60 in each FDR, 10; PC at age Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5524. doi:1538-7445.AM2012-5524