Neurodegenerative disease detection and severity prediction using deep learning approaches

Abstract Neurodegenerative diseases (NDDs) such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and Parkinson's disease (PD) can manifest themselves anatomically by degeneration in the brain as well as motor symptoms. The motor symptoms can affect walking dynamics in a disease-specific fashion; characteristically they disrupt gait. As the severity of the disease increases, walking ability deteriorates. We examined the effect of NDDs such as ALS, HD, and PD on gait and developed a convolutional long short-term memory (ConvLSTM) and three-dimensional convolutional learning network (3D CNN)-based approach to detecting neurodegenerative conditions and predicting disease severity.