Predicting Vitality Change in Older Breast Cancer Survivors after Primary Treatment--an Approach Based on Using Time-related Difference of Pro-inflammatory Marker C-reactive Protein.
2016
Backround: We aimed to determine prognosis of vitality change
and functional status of breast cancer survivors after primary
oncological treatment using time-related differences of
elevated levels of highly sensitive proinflammatory C-reactive
protein (CRP). Patients and Methods: The test group consisted
of 46 elderly breast cancer survivors (median age was 65 years)
who completed Vitality Scale of Short Form 36 (SF-36) after
completing treatment and another retrospectively at diagnosis.
Data on tumor-related factors, treatment, and outcomes were
obtained retrospectively from medical records, and linear
regression analysis was performed. CRP was followed at
diagnosis and one year after primary treatment. Within the
scope of this study, clinically important difference in the
Vitality Scale was set at five points of change. Results:
Results showed a statistically significant relationship between
CRP change and vitality component of SF-36 change (rs = –
0.350, p = 0.023) in which a decrease in CRP inversely
correlated with the quality of life component. The overall
change was 1.078 of the vitality scale score (approximately 1
point) for each 1 unit decrease of CRP (1 mg/ L). Association
of CRP levels (before and after treatment, its difference
between these time points) with age, number of comorbidities
and stage of the disease was analyzed and no statistically
significant relationship was found in our study. Conclusion:
Preliminary results suggested time-related differences in
elevated CRP levels as a potentially suitable predictor for
change in vitality status for long term, chronic condition for
older breast cancer survivors. We suggest the interpretation
schema including an understanding that CRP change of 5 mg/ L
and more should be considered a potential risk factor for
subsequent negative clinical outcomes.
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