Increased high-density lipoprotein-3 binding to leukocytes following weight loss and improved glycemic control in type 2 diabetic patients.

This study evaluates the effect on high-density lipoprotein (HDL) binding activity in cultured granulocytes before and after metabolic control of non—insulin-dependent diabetes mellitus ([NIDDM] type 2 diabetes) patients. In 20 type 2 diabetic patients, diabetic control was accomplished by administration of oral antidiabetic agents and dietary restrictions. Adequate metabolic control was reflected by a decrease in the fasting glucose, glycosylated hemoglobin (HbA 1c ), mean insulin, and body mass index (BMI). After control of the diabetes, the mean HDL 3 cholesterol was increased from 0.918 ± 0.05 to 1.008 ± 0.05 mmol/L ( P P 3 maximum specific binding was higher after versus before diabetic control, 77 ± 6 versus 122 ± 8 ng/mg cell protein ( P max ] from 4.97 × 10 −10 to 8.3 × 10 −10 mol/L, P K d (from 1.47 × 10 −7 v 2.04 × 10 −7 mol/L). These results suggest that the metabolic control of type 2 diabetes increases HDL 3 binding activity.