273 New cardiac biomarkers after marathon in woman

In a prospective study we evaluated kinetic of hFABP, CAIII and GPBB during the 2008 Marathon du Medoc by 67 healthy volunteered. Blood were collected at baseline (T1), immediately after (T2) and 3 h after (T3). Biomarkers were assayed by Cardiac array on Evidence Investigator (EI) RANDOX, cTnI and myoglobine by Dimension RxL too. 10 (5%) TnIc values disagreed between RxL and EI, all at T2 and T3. cTnI (EI) was negative in all subjects before, increased transiently in 4 (6%) at T2 then normalized. Increased ratio of Myo to FABP from [4-46] to [5-1208] then [5-43] indicated that Myo was more likely to originate from muscle. hFABP normal at T1 but for one, increased for all but one at T2 [4->150] and T3 [5->150]. CAIII increased from [8-68 ng/mL] to [45->145] then [57->145] indicated skeletal muscle damage. GPBB baseline was in [2-7 ng/mL] but for one. 13 (19%) rates increased at T2 [8-27], which 7 returned to baseline after 3 h and 6 remained high. 6 (9%) increased only at T3 [8,5-141]. Combination of markers showed that by the 4 women who had elevated cTnI (T3), Myo, hFABP and CAIII increased in all cases and GPBB in two. GPBB, presented as released early from injured myocardial cells, increased however in 19 (28%) women after marathon. Moderate elevation of GPBB would more likely reflect active glycogenolysis and heart fatigue than injury. These new markers don’t offer adequate cardiospecificity to rule out myocardial damage in runners.