The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

Kensuke Kojima,Masaya Shimanuki,Masato Shikami,Ismael Samudio,Vivian Ruvolo,Paul Corn,Nobuyoshi Hanaoka,Marina Konopleva,Michael Andreeff,Hideki Nakakuma

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

2008

Kensuke Kojima
Masaya Shimanuki
Masato Shikami
Ismael Samudio
Vivian Ruvolo
Paul Corn
Nobuyoshi Hanaoka
Marina Konopleva
Michael Andreeff
Hideki Nakakuma

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

Keywords:

Genetics
Cancer research
RPTOR
Programmed cell death
mTORC2
PI3K/AKT/mTOR pathway
Signal transduction
Pi
Kinase
Apoptosis
Biology
Protein kinase B
Survivin

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

103

Citations