In vivo effects of bisphenol A exposure on haematological parame- ters in Korean rockfish, Sebastes schlegeli

This study was conducted to investigate the effect of bisphenol A (BPA; 4,4' -isopropylidenediphenol) on haematological parameters of Korean rockfish, Sebastes schlegeli in laboratory condition, Fish were randomly distributed into three treatment groups which were received of 0.1, 1 and 10 mg BPA body weight. They were injected four times intraperitoneally at days 0,3,7 and 12 with BPA. Control group was subjected to the same regime using an equal volume of 60% ethanol-mixed PBS carrier injection only. Fish from each group were sacrificed on day 15 after first injection for haematological assay. Observations on haematological parameters indicated BPA-treatment induced lower level of red blood cell counts and hemoglobin concentration. Serum chloride, calcium, glucose, bilirubin and blood urea nitrogen concentrations increased following exposure to BPA at 10 mg body weight. In contrast, serum cholesterol in fish exposed to BPA decreased. Serum transaminase and lactate dehydrogenase activities after the highest level of 10 mg PBA was significantly increased. These results demonstrate that BPA have induced adverse impact on haematological parameters in the Korean rockfish, Sebastes schlegeli.