In-vivo Monitoring der Angiogenese im Rahmen der Frakturheilung mittels USPIO-unterstützter MRT

Angiogensis is playing an important role during fracture healing. The aim of this study was the evaluation of steady-state USPIO enhanced MR blood volume measurements in a longitudinal study of angiogenesis in an experimental fracture model. The MR results estimated an increase of blood volume during fracture healing, which corelated wellwith the histological findings. Quantitative MR is thus expected tobe a helpful tool for the monitoring of neovascularization.