Studies pn aaribilhanrial drugs. IV. Experimental therapy of 12 new compounds given intraperitoneally in mice.

Intraperitoneal injections of 6stibonic acids and their relative compounds derived from sulfa-drugs, 3 dithiastibiols, 2 organotin compounds and 1 organomercury compound were studied for their therapeutic activities against schistosomiasis japonica in white mice. The LD_(10), LD_(50), or the minimal lethal doses were used for treatment, which was begun 5 weeks after exposure to 40 cercariae per mouse. The injections were given once daily for 14 days, and, after a holding period of another 14 days, the mice were autopsied. Basing on the average number of worms remained in each mouse, the therapeutic effects of out of the 12 compounds were better than that of tartar emetic.