Prognostic Features of Long-term Survivors After Surgical Management of Malignant Pleural Mesothelioma

Background The primary aim of this study was to evaluate prognostic features of long-term survivors with pleural mesothelioma. Methods Overall survival outcome was analyzed in 456 patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy (EPP), pleurectomy/decortications, or pleurodesis/biopsy with at least 18 months of follow-up. Prospectively collected clinicopathologic and treatment data were assessed for their correlations with actual 18-month survivors in both univariate and multivariate analyses. Results The actual 18-month survival was 28%. Epithelial subtype was present in 185 patients (41%) and nonepithelial subtype in 183 (40%). Procedures were EPP in 59 patients (13%), pleurectomy/decortication in 250 (55%), and pleurodesis/biopsy in 147 (32%). Forty-two patients (9%) underwent positron emission tomography (PET) scanning. Forty patients (9%) received adjuvant radiotherapy and 45 (10%) received postoperative pemetrexed combination chemotherapy. In univariate analysis, age 65 years or younger ( p p = 0.041), epithelial subtype ( p p p = 0.012), adjuvant radiotherapy ( p = 0.042), and postoperative pemetrexed combination chemotherapy ( p = 0.035) were strongly associated with 18-month survivors. In multivariate analysis, epithelial histopathologic subtype ( p p Conclusions The actual 18-month survival was 28% in 456 pleural mesothelioma patients who underwent operation. Epithelial histologic subtype and EPP were identified as independent predictors for 18-month survivors.