A prognostic criterion for the course of chronic recurrent pancreatitis

: Disorders in the blood kallikrein-kinin system presenting mainly with kallikrein elevation and accelerated rate of bradykinin release from kininogen, hyperhistaminemia and hyperserotoninemia may be considered natural for chronic recurrent pancreatitis at the height of its exacerbation. Despite attenuation of the aggravation some patients continue to exhibit the above changes. Upon the analysis of the prospective follow-up data, such patients develop more progressive deficiency of pancreatic enzymes as shown by repeated pancreozymin tests. This fact is under consideration in the discussion on the prognostic role of kallikrein-kinin system dysfunction, hyperhistaminemia and hyperserotoninemia persistent registration when advancing the remission of the disease.