Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

Estela G. Toraño,Gustavo F. Bayón,Álvaro del Real,Marta I. Sierra,María G. García,Antonella Carella,Thalía Belmonte,Rocío G. Urdinguio,Isabel Cubillo,Javier García-Castro,Jesus Delgado-Calle,Flor M. Pérez-Campo,José A. Riancho,Mario F. Fraga,Agustín F. Fernández

Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells

2016

Estela G. Toraño
Gustavo F. Bayón
Álvaro del Real
Marta I. Sierra
María G. García
Antonella Carella
Thalía Belmonte
Rocío G. Urdinguio
Isabel Cubillo
Javier García-Castro
Jesus Delgado-Calle
Flor M. Pérez-Campo
José A. Riancho
Mario F. Fraga
Agustín F. Fernández

Background Age-associated changes in genomic DNA methylation have been primarily attributed to 5-methylcytosine (5mC). However, the recent discovery of 5-hydroxymethylcytosine (5hmC) suggests that this epigenetic mark might also play a role in the process.

Keywords:

Bone marrow
CpG site
Methylation
Chromatin
DNA methylation
5-Methylcytosine
Immunology
Mesenchymal stem cell
Epigenetics
Biology

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